We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three.
Why this should be is one of modern medicine's greatest puzzles.
In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK.
We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.
Watch the full documentary now (playlist - 48 minutes)